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同質異構形構之蔗糖與其製造方法 Sucrose of new conformational polymorphs and manufacturing method thereof
專利名稱 同質異構形構之蔗糖與其製造方法 Sucrose of new conformational polymorphs and manufacturing method thereof
申請日 (校編號) 2009/09/21  (098003US)
專利證書號 8,273,873 美國
專利權人 國立中央大學
發明人 李 度、陳君達


技術摘要:
A sucrose of a conformational polymorph and its manufacturing method are disclosed. The sucrose is a Form II sucrose having a melting point of 140-180.degree. C., and furfuryl alcohol is added into a saturated sucrose solution by a reverse solution method, such that the saturated solution is recrystallized to form a new sucrose. The sucrose of this conformational polymorph has a melting point lower than the melting point of a general Form I sucrose, and the solubility of the Form II sucrose is different from the solubility of the Form I sucrose. Thus the Form II sucrose can be used as an excipient of medicines, sacrificial fiber blood vessel network structure for cell cultivations, or the manufacture of an optical interference wavy device. Since the hydrogen bonds in the molecular structure of the Form II sucrose and the Form I sucrose are different, the mechanoluminescence of the sucrose is affected.本發明係揭露一種同質異構形構(Polymorphism)之蔗糖及其製造方法,此同質異構形構之蔗糖(Form II)係為單一形構,熔點為140-180℃,係利用反溶劑法在飽和蔗糖溶液中添加糠醇,使此飽和溶液再結晶出新的蔗糖而得之。此同質異構形構之蔗糖的熔點較一般蔗糖(Form I)的熔點低,且Form II的溶解度與Form I不同,可作為藥物上之賦形劑、作為細胞培養的犧牲纖維血管網狀結構或用在光學干涉波紋元件的製造。另,由於Form II與Form I的分子結構上之氫鍵結不同,亦可影響蔗糖的機械發光(mechanoluminescence)的性質。

解決的問題或達成的功效:
It is a primary objective of the present invention to solve the sucrose purity and non-single morph issues of the prior art by providing a sucrose of a new conformational polymorph. The present invention is characterized in that a reverse solution method is used, wherein a furfuryl alcohol is added into a saturated sucrose solution, such that the saturated solution is recrystallized to form a purified Form II sucrose of the conformational polymorph. This sucrose has a melting point of 140-180.degree. C. and its differential scanning calorimetry (DSC) shows only one peak, and sucrose of this sort can be used as a medicine excipient. 提供一種同質異構形構之蔗糖,以解決蔗糖純化及不具單一形構之問題

應用領域:
The present invention relates to sucrose, in particular to a sucrose of two conformational polymorphs and its manufacturing method. 同質異構形構之蔗糖及其製造

適用產品:
蔗糖

IPC:
C13B-030/14(2011.01);A61K-031/715(2006.01); C13F-001/14(2006.01);A61K-031/715(2006.01)

Claim 1:
1. A purified Form II sucrose consisting of a single crystalline form, having a differential scanning calorimetry (DSC) result which shows one peak only, at approximately 150.degree. C., characterized in that a reverse solution method is used to perform a reaction by adding furfuryl alcohol into a saturated Form I sucrose solution at a ratio of 1:1, wherein the Form I sucrose solution is equal to 2873 mg of sucrose per mL of water, while maintaining the reaction at 60.degree. C., and stirring with a rotation speed of 500 rpm, such that the saturated Form I sucrose solution is recrystallized to yield the purified Form II sucrose; wherein the purified Form II sucrose has a melting point of 140-180.degree. C.; and wherein the purified Form II sucrose has a solubility of 2.15-2.20 g/ml at 25.degree. C. 1.一種同質異構形構之蔗糖,其特徵係為利用反溶劑法在一飽和蔗糖溶液中添加一糠醇,使該飽和蔗糖溶液再結晶而得之該同質異構形構之蔗糖。

聯繫方式
聯絡人:研發處智權技轉組 與我連絡
電話:03-4227151 #27076、27077 網址:http://www.caic.ncu.edu.tw/
地 址: 32001桃園市中壢區中大路300號
 
                 
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